The Molybdenum Centers of Xanthine Oxidase and Xanthine Dehydrogenase
نویسندگان
چکیده
منابع مشابه
Xanthine oxidase and xanthine dehydrogenase from an estivating land snail.
During arousal from estivation in land snails, Otala lactea, active metabolic functions are restored within minutes and oxygen consumption increases dramatically. During the transition from the hypoxic conditions of estivation to normoxia it is possible that xanthine oxidase (XO) in hepatopancreas contributes to the observed lipid peroxidation. Using a fluorometric assay that is based on the ox...
متن کاملIsolation and Identification of the Xanthine Oxidase Factor as Molybdenum*
The establishment and maintenance of normal levels of xanthine oxidase (X0) in the liver and intestine of weanling rats were previously shown (l-3) to be dependent upon an adequate diet. With a purified synthetic ration containing adequate riboflavin, two dietary factors were shown to be essential for this response: (1) protein, and (2) a hitherto unidentified substance referred to as the “live...
متن کاملPhosphorylation of xanthine dehydrogenase/oxidase in hypoxia.
The enzyme xanthine oxidase (XO) has been implicated in the pathogenesis of several disease processes, such as ischemia-reperfusion injury, because of its ability to generate reactive oxygen species. The expression of XO and its precursor xanthine dehydrogenase (XDH) is regulated at pre- and posttranslational levels by agents such as lipopolysaccharide and hypoxia. Posttranslational modificatio...
متن کاملIdentification of the xanthine oxidase factor as molybdenum.
The establishment and maintenance of normal levels of xanthine oxidase (X0) in the liver and intestine of weanling rats were previously shown (l-3) to be dependent upon an adequate diet. With a purified synthetic ration containing adequate riboflavin, two dietary factors were shown to be essential for this response: (1) protein, and (2) a hitherto unidentified substance referred to as the “live...
متن کاملInborn errors of molybdenum metabolism: combined deficiencies of sulfite oxidase and xanthine dehydrogenase in a patient lacking the molybdenum cofactor.
A patient suffering from a combined deficiency of sulfite oxidase (sulfite dehydrogenase; sulfite:ferricytochrome c oxidoreductase, EC 1.8.2.1) and xanthine dehydrogenase (xanthine:NAD+ oxidoreductase, EC 1.2.1.37) is described. The patient displays severe neurological abnormalities, dislocated ocular lenses, and mental retardation. Urinary excretion of sulfite, thiosulfate, S-sulfocysteine, ta...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.33.19209